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Cryosurgery is the process of destroying a skin cancer (lesion) by freezing it with liquid nitrogen. Liquid nitrogen is applied to the lesion using a cotton applicator stick or an aerosol spray.
The skin may first be numbed with a local anesthetic. The liquid nitrogen is applied or sprayed onto the cancer and the immediate surrounding tissue. The application may be repeated. An antibiotic dressing may be applied to the wound.
Cryosurgery is often used to destroy precancerous skin lesions such as actinic keratoses but is rarely used alone (monotherapy) to treat skin cancer.
An area where skin tissue has been destroyed by freezing with liquid nitrogen usually heals in 3 to 6 weeks. After the procedure, keep the wound clean and dry. A scab will form over the area.
Cryosurgery is used more often for precancerous growths such as actinic keratoses than for skin cancer.
Cryosurgery is done to destroy skin cancer if:
Cryosurgery is the treatment of choice for superficial actinic keratoses. And it often is successful in treating small lesions of squamous cell carcinoma in situ.footnote 1
If cryosurgery is used to treat skin cancer, there is a small chance that the skin cancer will return after treatment. One study that followed people for 5 years after treatment found that cryosurgery had a cure rate for 99 out of 100 people.footnote 2
The risks of cryosurgery include:
Cryosurgery is an efficient procedure if there are many skin cancers that need to be destroyed or treated.
Cryosurgery wounds heal slowly and can be painful.
Cryosurgery destroys tissue, so there is no way to obtain a sample (biopsy) for diagnosis.
Habif TP (2010). Premalignant and malignant nonmelanoma skin tumors. In Clinical Dermatology: A Color Guide to Diagnosis and Therapy, 5th ed., pp. 801-846. Edinburgh: Mosby Elsevier.
Carucci JA, et al. (2012). Basal cell carcinoma. In LA Goldman et al., eds., Fitzpatrick's Dermatology in General Medicine, 8th ed., vol. 1, pp. 1294-1303. New York: McGraw-Hill.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineKathleen Romito, MD - Family MedicineAmy McMichael, MD - Dermatology
Current as ofMarch 28, 2018
Current as of:
March 28, 2018
E. Gregory Thompson, MD - Internal Medicine
& Kathleen Romito, MD - Family Medicine & Amy McMichael, MD - Dermatology
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