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Movement problems (motor fluctuations) are the most common complication of long-term levodopa use. The majority of people who take levodopa develop these problems within 5 to 10 years. The main types of levodopa-related motor fluctuations include:
Motor fluctuations sometimes can be reduced or delayed by changing the schedule and amount of levodopa. Other medicines may be added to levodopa to help with motor fluctuations, such as dopamine agonists, COMT inhibitors, or MAO-B inhibitors. Increasingly, doctors are using dopamine agonists for initial treatment of Parkinson's disease, especially in younger people, to delay the development of motor fluctuations that eventually occur with long-term levodopa therapy.
ByHealthwise StaffPrimary Medical ReviewerAnne C. Poinier, MD - Internal MedicineAdam Husney, MD - Family MedicineMartin J. Gabica, MD - Family MedicineKathleen Romito, MD - Family MedicineSpecialist Medical ReviewerG. Frederick Wooten Jr., MD - Neurology
Current as ofOctober 9, 2017
Current as of:
October 9, 2017
Anne C. Poinier, MD - Internal Medicine
& Adam Husney, MD - Family Medicine & Martin J. Gabica, MD - Family Medicine & Kathleen Romito, MD - Family Medicine & G. Frederick Wooten Jr., MD - Neurology
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