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Ioannis Koktzoglou , PhD

Research Scientist III
Department of Radiology
Center for Advanced Imaging

Senior Clinician Researcher
University of Chicago, Pritzker School of Medicine

Contact Information

 847.570.4288
 847.570.2942 Fax
mailto:ikoktzoglou@northshore.org

Education

  • Ph.D. in Biomedical Engineering, Northwestern University, Evanston, IL, 2006
  • M.S. in Biomedical Engineering, Northwestern University, Evanston, IL, 2004
  • B.S. in Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 2002

Research and Academic Interests

Our lab develops and validates next-generation magnetic resonance imaging (MRI) technologies for evaluating cardiovascular disease, with a particular emphasis on accurate, reliable, and patient-friendly methods for assessing vascular disease throughout the body. Our research ranges from the development of altogether new MRI acquisition and reconstruction methods, to the validation of these innovative methods for diagnosing human disease.

Career Summary

Ioannis Koktzoglou, PhD is a Research Scientist at NorthShore University HealthSystem Research Institute and a Senior Clinician Researcher at the University of Chicago Pritzker School of Medicine who specializes in cardiovascular magnetic resonance imaging.  He received his Bachelor's degree in Computer Engineering from the University of Illinois at Urbana-Champaign as well as his Master's and Doctoral degrees in Biomedical Engineering from Northwestern University. At Northwestern, his doctoral research focused on the development of novel three-dimensional magnetic resonance imaging (MRI) techniques that enable high-resolution evaluation of arterial disease (i.e. atherosclerosis).  Dr. Koktzoglou's doctoral research was instrumental in transitioning the field away from legacy two-dimensional methods, to more informative and state-of-the-art three-dimensional MRI techniques.  At NorthShore Research Institute, he has developed an array of advanced MRI technologies for vascular imaging that do not require the use of intravenous contrast agents. One of these methods has since become commercially available to improve patient care and safety throughout the world.  Dr. Koktzoglou has previously served as faculty within the Northwestern University Feinberg School of Medicine.  He has served as principal investigator and co-investigator on projects supported by the National Institutes of Health and American Heart Association, authored or co-authored over 60 peer-reviewed journal publications, delivered or contributed to over 150 presentations at international scientific meetings, and is an inventor of 12 issued patents.

Honors and Awards

  • Distinguished Reviewer, Magnetic Resonance in Medicine, 2011, 2014-2015, 2017-2019
  • Distinguished Reviewer, Journal of Magnetic Resonance Imaging, 2012-2013, 2015, 2017-2018
  • Early Career Reviewer Program, National Institutes of Health, 2015
  • Pohost Best Paper Award Finalist, Journal of Cardiovascular Magnetic Resonance, 2008
  • Research Scholar Award, The Auxiliary of Evanston Northwestern Healthcare, 2007-2009
  • Student Stipend Award, International Society for Magnetic Resonance in Medicine, 2004-2006
  • Invited Young Researcher, 55th Meeting of Nobel Prize Winners, Lindau, 2005
  • Dr. John N. Nicholson Fellowship, The Graduate School, Northwestern University, 2003-2006
  • Biomedical Engineering Departmental Fellowship, Northwestern University, 2002
  • High Honors Graduate, University of Illinois College of Engineering, 2002
  • Dad’s Association Book Award, University of Illinois at Urbana-Champaign, 2001
  • Accenture Outstanding Engineering Student Award, University of Illinois, 2001
  • Frank C. Mock Scholarship, University of Illinois at Urbana-Champaign, 2001
  • Jules D. Falzer Memorial Scholarship, University of Illinois at Urbana-Champaign, 2000-2001
  • AHEPA Scholarship, 1998-1999
  • Dean’s List, University of Illinois at Urbana-Champaign, 1998-2002

Professional Memberships/Affiliations/Activities

  • Member, International Society for Magnetic Resonance in Medicine
  • Member, Society for Cardiovascular Magnetic Resonance

Scholarly Work

Peer-Reviewed Journal Publications:

  1. A. Varga-Szemes, A.E. Aherne, U.J. Shoepf, T.M. Todoran, I. Koktzoglou, R.R. Edelman. "Free-Breathing Fast Low-Angle Shot Quiescent-Interval Slice-Selective MR Angiography for Improved Detection of Vascular Stenoses in the Pelvis and Abdomen," in press at Investigative Radiology.
  2. A.U. Cavallo, I. Koktzoglou, R.R. Edelman, R. Gilkeson, G. Mihai, T. Shin, S. Rajagopalan. "Non-Contrast Magnetic Resonance Angiography for the Diagnosis of Peripheral Vascular Disease," JACC:Cardiovascular Imaging. 2019 May;12(5):e008844. doi: 10.1161/CIRCIMAGING.118.008844.
  3. I. Koktzoglou, E.A. Aherne, M.T. Walker, J.R. Meyer, R.R. Edelman. "Ungated Nonenhanced Radial Quiescent Interval Slice-Selective (QISS) Magnetic Resonance Angiography of the Neck: Evaluation of Image Quality," J Magn Reson Imaging. 2019 May 11. doi: 10.1002/jmri.26781. [Epub ahead of print]
  4. M.S. Ravesh, P. Langguth, J.A. Pfarr, J. Schupp, J. Trentmann, I. Koktzoglou, R.R. Edelman, J. Graessner, A. Greiser, D. Hautemann, A. Hennemuth, M. Both, O. Jansen, J. Hovener, J.P. Schafer. "Non-contrast-enhanced magnetic resonance imaging for visualization and quantification of endovascular aortic prosthesis, their endoleaks and aneurysm sacs at 1.5T," Magn Reson Imaging. 2019 May 7;60:164-172.
  5. A. Serhal, I. Koktzoglou, R.R. Edelman. "Feasibility of Image Fusion for Concurrent Magnetic Resonance Evaluation of Vessel Lumen and Vascular Calcifications in Peripheral Arterial Disease," in press at AJR A J Roentgenol. 2019 Apr;212(4):914-918.
  6. R.R Edelman and I. Koktzoglou. "Noncontrast MR Angiography: An Update," J Magn Reson Imaging. 2019 Feb;49(2):355-373.
  7. A. Serhal, I. Koktzoglou, P.Aouad, S. Giri, J.C. Carr, O. Morcos, R.R. Edelman. "Magnetic Resonance Imaging of Aorto-Iliac and Ilio-Femoral Vascular Calcifications using Proton Density-Weighted In-Phase Stack of Stars" J Cardiovasc Magn Reson. 2018 Aug 6; 20:51.
  8. D. Shen, R.R. Edelman, J.D. Robinson, H. Haji-Valizadeh, M. Messina, S. Giri, I. Koktzoglou, C.K. Rigsby, D. Kim. Single-Shot Coronary Quiescent-Interval Slice-Selective Magnetic Resonance Angiography Using Compressed Sensing: A Feasibility Study in Patients with Congenital Heart Disease. J Comput Assist Tomogr. 2018 Jun 28. doi: 10.1097/RCT.0000000000000760. [Epub ahead of print]
  9. W. Li, I. Koktzoglou, E.E. Dunkle, R.R. Edelman. "Therapeutic Iron Infusion Causing Delayed Venous Contamination in Magnetic Resonance Angiography," Ann Clin Case Rep. 2018; 3: 1497.
  10. R.R. Edelman, A. Serhal, A. Pursnani, J. Pang, I. Koktzoglou. "Cardiovascular Cine Imaging and Flow Evaluation Using Fast Interrupted Steady-State (FISS) Magnetic Resonance," J Cardiovasc Magn Reson. 2018 Feb 19;20(1):12.
  11. R.R. Edelman, M. Carr, I. Koktzoglou. "Advances in Non-Contrast Quiescent-Interval Slice-Selective MRA," Clinical Radiol. 2018 Jan 11. pii: S0009-9260(17)30567-6. doi: 10.1016/j.crad.2017.12.003. [Epub ahead of print]
  12. I. Koktzoglou and R.R. Edelman. "Radial Fast Interrupted Steady-State Magnetic Resonance Imaging," Magn Reson Med. 2018 Apr;79(4):2077-2086.
  13. R.R. Edelman, R. Silvers, K. Thakrar, M. Metzl, J. Nazari, S. Giri, I. Koktzoglou. "Nonenhanced, MR Angiography of the Pulmonary Arteries using Single-Shot Radial Quiescent-Interval Slice-Selective (QISS): A Technical Feasibility Study," J Cardiovasc Magn Reson. 2017 Jun 30;19(1):48.
  14. I. Koktzoglou and R.R. Edelman. "Super-Resolution Intracranial Quiescent Interval Slice-Selective Magnetic Resonance Angiography," Magn Reson Med. 2018 Feb;79(2):683-691.
  15. R.P. Lim, E. Trajcevska, Y. Perchyonok, D. Gooneratne, G. Fitt, A. Kemp, T. Spelman, S. Giri, D. Piccini, R.R. Edelman, M. Simpson, H. Dewey, G. Ng, I. Koktzoglou, "Non-Contrast Hybrid Arterial Spin Labeled Imaging of the Intracranial Arteries," J Comput Assist Tomogr. 2017 Nov/Dec;41(6):854-860.
  16. R.R. Edelman, M.P.F. Botelho, A. Pursnani, S. Giri, I. Koktzoglou. "Improved Dark Blood Imaging of the Heart using Radial Balanced Steady-State Free Precession," J Cardiovasc Magn Reson, 2016, 18:69.
  17. M.P.F. Botelho, I. Koktzoglou, J. Collins, S. Giri, J.C. Carr, N. Gupta, R.R. Edelman. "MR Imaging of Ilio-Femoral Peripheral Vascular Calcifications using Proton Density-Weighted, In-Phase 3D Stack-Of-Stars Gradient-Echo," Magn Reson Med. 2017 Jun;77(6):2146-2152.
  18. I. Koktzoglou, M.T. Walker, J.R. Meyer, I.G. Murphy, R.R. Edelman. "Nonenhanced Hybridized Arterial Spin Labeled Magnetic Resonance Angiography of the Extracranial Carotid Arteries using a Fast Low Angle Shot Readout at 3 Tesla," J Cardiovasc Magn Reson, 2016;18:18.
  19. R.R. Edelman, S. Giri, A. Pursnani, M.P.F. Botelho, W. Li, I. Koktzoglou. "Breath-Hold Imaging of the Coronary Arteries using Quiescent-Inflow Slice-Selective (QISS) Magnetic Resonance Angiography: Pilot Study at 1.5 Tesla and 3 Tesla," J Cardiovasc Magn Reson, 2015;17:101.
  20. I. Koktzoglou, I.G. Murphy, S. Giri, R.R. Edelman. "Quiescent Interval Low Angle Shot Magnetic Resonance Angiography of the Extracranial Carotid Arteries," Magn Reson Med, 2016; 75(5):2072-7.
  21. R.P. Lim and I. Koktzoglou. "Non-Contrast MRA: Concepts and Clinical Applications," Radiologic Clinics of North America, 2015; 53(3):457-476.
  22. I. Koktzoglou, S. Giri, D. Piccini, D.M. Grodzki, I.G. Murphy, O. Flanagan, N. Gupta, J.D. Collins, R.R. Edelman. "Arterial Spin Labeled Carotid MR Angiography: A Phantom Study Examining the Impact of Technical and Hemodynamic Factors," Magn Reson Med, 2016; 75(1):295-301.
  23. R.R. Edelman, S. Giri, I.G. Murphy, O. Flanagan, P. Speier, I. Koktzoglou. "Ungated Radial Quiescent-Inflow Single-Shot (UnQISS) Magnetic Resonance Angiography Using Optimized Azimuthal Equidistant Projections," Magn Reson Med, 2014; 72(6):1522-9.
  24. R.R. Edelman, O. Flanagan, D. Grodzki, S. Giri, I. Koktzoglou. "Projection MR Imaging of Peripheral Calcifications," Magn Reson Med, 2015; 73(5):1939-45.
  25. I. Koktzoglou, J.R. Meyer, W.J. Ankenbrandt, S. Giri, D. Piccini, M.O. Zenge, O. Flanagan, T. Desai, N. Gupta and R.R. Edelman. "Arterial Spin Labeled Carotid MR Angiography Using 3D Radial Balanced Steady State Free Precession Imaging," J Magn Reson Imaging, 2015; 41(4):1150-6.
  26. P. Amin, I. Koktzoglou, J.D. Collins, J.C. Carr, R.R. Edelman. "Evaluating Peripheral Arterial Disease with Nonenhanced Quiescent-Interval Single-Shot MR Angiography at 3 Tesla," AJR Am J Roentgenol, 2014; Apr;202(4):886-93.
  27. I. Koktzoglou, C.A. Mistretta, S. Giri, P. Amin, R.R. Edelman. "Simultaneous static and cine nonenhanced MR angiography using radial sampling and highly constrained back projection reconstruction," Magn Reson Med, 2013; 72(4):1079-86.
  28. H. Tan, I. Koktzoglou, P.V. Prasad. "Renal Perfusion Imaging with Two-Dimensional Navigator Gated Arterial Spin Labeling," Magn Reson Med, 2014; 71(2):570-9.
  29. I. Koktzoglou. "4D Dark Blood Arterial Wall Magnetic Resonance Imaging: Methodology and Demonstration in the Carotid Arteries," Magn Reson Med, 2013; 69(4):956-65.
  30. R.R. Edelman, E.E. Dunkle, S. Giri, M. Galizia, P. Amin, I. Koktzoglou. "Quiescent-Inflow Single-Shot (QISS) Magnetic Resonance Angiography Using a Highly Undersampled Radial k-Space Trajectory," Magn Reson Med, 2012; 70(6):1662-8.
  31. I. Koktzoglou. "Gray Blood Magnetic Resonance for Carotid Arterial Wall Imaging and Visualization of Deep-Seated and Superficial Vascular Calcifications," Magn Reson Med, 2012; 70(1):75-85.
  32. H. Tan, I. Koktzoglou, C. Glielmi, R.R. Edelman. "Optimization of Single Shot 3D Breath-hold Nonenhanced MR Angiography of the Renal Arteries," J Cardiovasc Magn Reson, 2012;19:30.
  33. F.E. Mordini, I. Koktzoglou, R.R. Edelman. "Time-Resolved Spin-Labeled Balanced Steady-State Free Precession Cineangiography for Visualizing Intracardiac Shunt: Technical Considerations and Clinical Feasibility," Magn Reson Med, 2012; 68:1798-806.
  34. E.J. Offerman, I. Koktzoglou, C. Glielmi, A. Sen, R.R. Edelman. "Prospective Self-Gated Nonenhanced Magnetic Resonance Angiography of the Peripheral Arteries," Magn Reson Med, 2012; 69:158-62.
  35. P.A. Hodnett, E.V. Ward, A.H. Davarpanah, T.A. Scanlon, J.D. Collins, C.B. Glielmi, X. Bi, I. Koktzoglou, N. Gupta, J.C. Carr, R.R. Edelman. "Peripheral Arterial Disease in a Symptomatic Diabetic Population: Prospective Comparison of Rapid Unenhanced MR Angiography (MRA) with Contrast-Enhanced MRA," AJR A J Roentgenol, 2011; 197:1466-73.
  36. I. Koktzoglou, N. Gupta, R.R. Edelman. "Non-Enhanced Extracranial Carotid MR Angiography Using Arterial Spin Labeling: Improved Performance with Pseudocontinuous Tagging," J Magn Reson Imaging, 2011; 34:384-94.
  37. P.A. Hodnett, I. Koktzoglou, A.H. Davarpanah, T.G. Scanlon, J.D. Collins, J.J. Sheehan, E.E. Dunkle, N. Gupta, J.C. Carr, R.R. Edelman. "Evaluation of peripheral arterial disease with nonenhanced quiescent-interval single shot MR angiography," Radiology, 2011; 260:282-93.
  38. E.J. Offerman, P.A. Hodnett, R.R Edelman, I. Koktzoglou. "Nonenhanced Methods for Lower-Extremity MRA: A Phantom Study Examining the Effects of Stenosis and Pathologic Waveforms at 1.5T," J Magn Reson Imaging, 2011, 33:401-408.
  39. I. Koktzoglou, J.J. Sheehan, E.E. Dunkle, F.A. Breuer, R.R. Edelman. "Highly-accelerated contrast-enhanced MR angiography: improved reconstruction accuracy and reduced noise amplification with complex subtraction," Magn Reson Med, 2010; 64:1843-8.
  40. M. Haque, I. Koktzoglou, P.V. Prasad. "Functional Magnetic Resonance Imaging of Liver Using BOLD MRI: Effect of Glucose," J Magn Reson Imaging, 2010; 32:988-91.
  41. K.S. McCommis, I. Koktzoglou, H. Zhang, T.A. Goldstein, B.E. Northrup, D. Li, R.J. Gropler, J. Zheng. "Improvement of hyperemic myocardial oxygen extraction fraction estimation by a diffusion-prepared sequence," Magn Reson Med, 2010; 63:1675-82.
  42. Y. Wu, A.B. Ragin, H. Du, S. Sidharthan, E.E. Dunkle, I. Koktzoglou, R.R. Edelman. "Sub-millimeter isotropic MRI for segmentation of subcortical brain regions and brain visualization," J Magn Reson Imaging, 2010; 31:980-6.
  43. S.A Tsaftaris, E.J. Offerman, R.R. Edelman, I. Koktzoglou, "Fully Automated Reconstruction of Ungated Ghost Magnetic Resonance Angiograms," J Magn Reson Imaging, 2010; 31:655-62.
  44. R.R. Edelman, J.J. Sheehan, E.E. Dunkle, N. Schindler, J.C. Carr, I. Koktzoglou, "Quiescent interval single shot unenhanced magnetic resonance angiography of peripheral vascular disease: technical considerations and clinical feasibility," Magn Reson Med, 2010; 63:951-8.
  45. R. Dharmakumar, Z. Zhang, I. Koktzoglou, S.A. Tsaftaris, D. Li, "Dual Contrast Cellular MRI," Mol Imaging, 2009; 8:254-63.
  46. R.R. Edelman, I. Koktzoglou, W.J. Ankenbrandt, E.E. Dunkle, "Cerebral venography using fluid-suppressed STARFIRE," Magn Reson Med, 2009; 61:1515-9.
  47. I. Koktzoglou and R.R. Edelman, "Ghost Magnetic Resonance Angiography," Magn Reson Med, 2009; 61:1515-9.
  48. R.R. Edelman, E.E. Dunkle, I. Koktzoglou, A. Griffin, E.J. Russell, W.J. Ankenbrandt, A.B. Ragin, A. Carrillo, "Rapid Whole-Brain Magnetic Resonance Imaging with Isotropic Resolution at 3 Tesla," Investigative Radiology, 2009; 44:54-9.
  49. F. Mordini, S. Smart, I. Koktzoglou, "MRI for Plaque Assessment: An Overview of the Literature," Cardiac Interventions Today, 2008; 50-4.
  50. I. Koktzoglou and R.R. Edelman, "STAR and STARFIRE for flow-dependent and flow-independent carotid MRA" Magn Reson Med, 2009; 61:117-24.
  51. R.R. Edelman and I. Koktzoglou, "Unenhanced flow-independent MR venography by using signal targeting alternative radiofrequency and flow-independent relaxation enhancement" Radiology, 2009; 250:236-45.
  52. I. Koktzoglou and R.R. Edelman, "Fast Projective Carotid MR Angiography with Arterial Spin-Labeled Balanced SSFP," J Magn Reson Imaging, 2008; 28:778-82.
  53. R. Dharmakumar, I. Koktzoglou, D. Li, "Off-resonance positive contrast imaging of a passive endomyocardial catheter in swine," Phys Med Biol, 2008; 53(13):N249-57.
  54. I. Koktzoglou, A. Kirpalani, T.J. Carroll, D. Li, J.C. Carr, "Dark-blood MRI of the thoracic aorta with 3D diffusion-prepared SSFP: initial clinical evaluation," AJR A J Roentgenol, 2007; 189(4):966-72.
  55. I. Koktzoglou, D. Li, R. Dharmakumar, "Dephased FLAPS for improved visualization of susceptibility-shifted passive devices for real-time interventional MRI," Phys Med Biol, 2007; 52:N277-86.
  56. R. Dharmakumar, I. Koktzoglou, D. Li, "Factors influencing fast low angle positive contrast with steady-state free precession (FLAPS) magnetic resonance imaging," Phys Med Biol, 2007; 52:3261-73.
  57. I. Koktzoglou and D. Li, "Sub-Millimeter Isotropic Resolution Carotid Wall MRI with Swallowing Compensation: Imaging Results and Semi-Automated Wall Morphometry," J Magn Reson Imaging, 2007; 25:815–23.
  58. I. Koktzoglou, Y.C. Chung, T.J. Carroll, MD Morasch, O.P. Simonetti, D. Li, "Three-Dimensional Black-Blood MR Imaging of the Carotid Arteries with Segmented Steady-State Free Precession – Initial Experience," Radiology, 2007; 243:220-8.
  59. I. Koktzoglou and D. Li, "Diffusion-Prepared Segmented Steady-State Free Precession: Application to 3D Black-Blood Cardiovascular Magnetic Resonance of the Thoracic Aorta and Carotid Arteries," J Cardiovasc Magn Reson, 2007; 9:33-42.
  60. R. Dharmakumar, I. Koktzoglou, D. Li, "Generating Positive Contrast from Off-Resonant Spins with Steady-State Free Precession Magnetic Resonance Imaging: Theory and Proof-of-Principle Experiments," Phys Med Biol, 2006; 51:4201-15.
  61. I. Koktzoglou, Y.C. Chung, V. Mani, T.J. Carroll, MD Morasch, G. Mizsei, O.P. Simonetti, Z.A. Fayad, D. Li, "Multi-slice Dark-Blood Carotid Artery Wall Imaging: A 1.5T and 3.0T Comparison," J Magn Reson Imaging, 2006; 23:699-705.
  62. I. Koktzoglou, K.R. Harris, R. Tang, B.J. Kane, B. Misselwitz, H.J. Weinmann, B. Lu, A. Nagaraj, S.I. Roth, T.J. Carroll, D.D. McPherson, D. Li, "Gadofluorine-Enhanced Magnetic Resonance Imaging of Carotid Atherosclerosis in Yucatan Miniswine," Investigative Radiology, 2006; 41:299-304.
  63. I. Koktzoglou, O.P. Simonetti, D. Li, "Coronary Artery Wall Imaging: Initial Experience at 3T," J Magn Reson Imaging, 2005; 21:128-32.

U.S. Patents:

  • “System and Method for Ghost Magnetic Resonance Imaging” United States Patent 8,154,287. Issued 4/10/2012.
  • “Parallel-Accelerated Complex Subtraction MRI” United States Patent 8,274,284. Issued 9/25/2012.
  • “Time Resolved Spin Labeled MRI Cineangiography” United States Patent 8,441,257. Issued 5/4/2013.
  • “Method for Non-Contrast Enhanced Magnetic Resonance Angiography” United States Patent 8,744,551. Issued 6/3/2014.
  • "System and Method for Phase Contrast Imaging with Improved Efficiency" United States Patent 8,838,204. Issued 9/16/2014.
  • “System and Method for Ungated Non-Contrast Enhanced Magnetic Resonance Angiography” United States Patent 9,113,810. Issued 8/25/2015.
  • “System and Method for Imaging of Vascular Structures Using Non-Contrast Enhanced Magnetic Resonance Imaging” United States Patent 9,507,003. Issued 11/29/2016.
  • “System and Method for Imaging of the Vascular Components with Temporal Information and Suppressed Blood Pools Using Magnetic Resonance Imaging” United States Patent 9,968,276. Issued 5/15/2018.
  • “System and Method for Accelerated Angiographic Magnetic Resonance Imaging” United States Patent 10,061,006. Issued 8/28/2018.
  • “Systems and Methods for Efficient Radial Magnetic Resonance Imaging with Azimuthal Equidistant Projections” United States Patent 10,120,048. Issued 11/6/2018.
  • “Background-Suppressed, Reduced Field-Of-View Radial Magnetic Resonance Imaging” United States Patent 10,188,355. Issued 1/29/2019.
  • “System and Method for Neutral Contrast Magnetic Resonance Imaging of Calcifications” United States Patent 20150196223. Allowed 3/7/2019.

Peer Review Service:

  • Reviewer for multiple scientific journals, including:  Magnetic Resonance in Medicine, Journal of Magnetic Resonance Imaging, Journal of Cardiovascular Magnetic Resonance, Radiology, Circulation: Cardiovascular Imaging, American Journal of Roentgenology, Magn. Reson. Materials in Physics Biology & Medicine, PLOS ONE, NMR in Biomedicine, Clinical Medicine Cardiology, European Journal of Nuclear Medicine and Molecular Imaging, Korean Journal of Radiology, Medical Physics, Magnetic Resonance Imaging, American Journal of Neuroradiology